Omnipod® 5 Algorithm Enhancement FAQs for HCPs

Two key Omnipod® 5 algorithm enhancements will soon make automated insulin delivery more flexible and convenient. New compatible Pods with the same form factor will start to show up patients' refills at the pharmacy in early 2026.

Enhancements:

Lower Target Glucose Option

With a new, lower Target Glucose option of 100 mg/dL, you will have more customization than ever to choose the option that works best for each patient. Lower Target Glucose options can deliver more insulin when they need it.

Updated Advisory Alarm Behavior and Improved High Glucose Response

The new "Check Blood Glucose” advisory alarm is replacing the “Automated Delivery Restriction” advisory alarm. When the alarm is triggered for prolonged high glucose events, users remain in Automated Mode and continue to receive autocorrections based on insulin needs.

The new "Check Blood Glucose” advisory alarm is replacing the

“Automated Delivery Restriction” advisory alarm. This new alarm no longer requires the user to switch to Manual Mode for 5 minutes.

The alarm occurs when the System has been working to bring their glucose into range, but has not seen their sensor glucose change the way it expected. The alarm notification screen will indicate if they are trending high or low.

During high glucose events, once the alarm is triggered and the user acknowledges it, the System will now keep them in Automated Mode, continue to autocorrect based on insulin needs.

During low glucose events, when the alarm is triggered, the System will switch users to Automated: Limited Mode. Once the user acknowledges the alarm, the System will now automatically switch back to Automated Mode.

We are currently working to stock the updated Pods in pharmacies and estimate availability in early 2026.

The new features will require both an Omnipod 5 App software update and new updated Pods. If your patients are a currently using Omnipod® 5, they will receive an email communication when these features are available.

The new Pods will have a black dot with "R1". The black dot is located on the top right corner of the Tray Lid and 5-pack box label. Please see the images below for reference.  The Pod form factor is not changing with the addition of these

features.

Patients will also need the Omnipod® 5 App software update to unlock these features.

No, you will not need to write a new prescription. The new Pods will start to show up in refills at the pharmacy. You and your patients will then be able to take advantage of the 100 mg/dL Target Glucose.

No, they will not need a new Controller or App to use these new features. They will receive a software update to their Controller and/or Omnipod® 5 App on their compatible smartphone. That will unlock the new features.  

They will need to use the new compatible Pods.

Yes, after you consult with your patient about setting the target glucose setting to 100 mg/dL, the Target Glucose target setting need to be changed to 100 mg/dL in the Omnipod® 5 App.

Will patients be notified when these features are available?

Yes, both Pods that are compatible with Dexcom and FreeStyle Libre sensors will be updated to include these new features.

The updated Omnipod® 5 algorithm was tested using simulated data, which means computer simulations were used instead of conducting a clinical trial. For more information reach out to our Medical Information team at [email protected].