Omnipod® 5 Algorithm Enhancement and FreeStyle Libre 3 Plus Sensor Integration FAQs for HCPs

Two key Omnipod® 5 algorithm enhancements and expanded sensor integration will soon make automated insulin delivery more flexible and convenient. Compatible Pods with the same form factor will begin to appear in patients’ refills at the pharmacy as retail inventory transitions through the summer of 2026.

New 100 mg/dL Target Glucose option
A new lower 100 mg/dL Target Glucose option for more time in range, with no meaningful impact on time below range¹, enabling more responsive insulin delivery.

Updated Advisory Alarm behavior and improved high glucose response
Omnipod 5 is designed for fewer interruptions to help users stay in Automated Mode, even during prolonged hyperglycemia by continuing to autocorrect every 5 minutes.

FreeStyle Libre 3 Plus sensor integration
Omnipod 5 will now integrate with the FreeStyle Libre 3 Plus sensor, giving patients more choices when transitioning to AID from MDI without having to learn a new sensor. Omnipod 5 will now be compatible with Dexcom G6 and G7 Series CGMs, the FreeStyle Libre 3 Plus sensor, and the FreeStyle Libre 2 Plus sensor.

The new Algorithm Enhancements, including the 100 mg/dL Target Glucose option, require both an Omnipod 5 App software update and compatible Pods. 

New-to-Omnipod 5 patients should be prescribed through ASPN pharmacy partners to access the newest Pod experience at launch. 

Existing Omnipod 5 users continuing with their current sensor and the appropriate compatible Pod for that sensor should continue refilling through their current pharmacy, compatible Pods will appear in refills as channel inventory transitions through the summer. Existing users switching sensor integrations, including switching to Omnipod 5 with the FreeStyle Libre 3 Plus sensor integration, should confirm the appropriate compatible Pod prescription with their healthcare provider.

For new-to-Omnipod 5 patients, prescribe through ASPN pharmacy partners to access the newest Pod experience at launch, including the new Algorithm Enhancements (the 100 mg/dL Target Glucose option) and the FreeStyle Libre 3 Plus sensor integration. 

For existing patients continuing with their current sensor and the appropriate compatible Pod for that sensor, continue prescribing through their current channel unless directed otherwise.

No, they will not need a new Controller or App to use these new features. They will receive a software update to their Controller and/or Omnipod® 5 App on their compatible smartphone. That will unlock the new features.  

They will need to use the new compatible Pods.

If patients are currently using Omnipod® 5, they will receive an email communication when these features are available.

Prescribe to ASPN pharmacy partners when starting any new-to-Omnipod 5 patient. For existing patients seeking earlier access to the full Algorithm Enhancements, when clinically important, HCPs may use ASPN as a reactive pathway. 

ASPN cannot process prescriptions for plans that require local retail pickup, including certain Medicaid plans, these patients should continue through their in-network retail pharmacy and will receive compatible Pods as retail inventory transitions.

Patients already filling through an ASPN-affiliated pharmacy partner will receive compatible Pods through their normal refill process as channel inventory transitions. A new prescription is not required solely to access the new Algorithm Enhancements. If a patient is switching sensor integrations, follow standard prescribing guidance.

The new Check Blood Glucose Advisory Alarm replaces the Automated Delivery Restriction alarm. The key difference is that users no longer need to switch to Manual Mode for 5 minutes after acknowledging the alarm. 

During high glucose events, the System keeps users in Automated Mode and continues to autocorrect every 5 minutes. During low glucose events, the System switches to Automated Mode: Limited and automatically returns to Automated Mode once the user acknowledges the alarm.

Pods with the full Algorithm Enhancements suite are identified by a black dot with "R1" on the Tray Lid and box label. Users and HCPs can check either the Tray Lid or box to confirm compatibility.
Older Omnipod 5 Pods compatible with Dexcom G6 and FreeStyle Libre 2 Plus will not enable the new Algorithm Enhancements.
If the Tray Lid and box are no longer available, navigate to the About Screen in the Omnipod 5 App and check the Pod Software Version. Version 12.0 or greater confirms the Pod supports the full Algorithm Enhancements suite.

What happens first depends on your pharmacy’s available Pod inventory. The Omnipod 5 App software update is needed to enable the new Algorithm Enhancements, and it may arrive before compatible Pods appear in your refills. As pharmacy inventory transitions, existing Omnipod 5 users with a Dexcom CGM will automatically begin receiving compatible Pods in their refills.

Yes. Existing Omnipod 5 users can switch to Omnipod 5 with the FreeStyle Libre 3 Plus sensor integration. This requires a compatible Pod. A new Omnipod 5 prescription is not required for previous Omnipod 5 with FreeStyle Libre 2 Plus sensor users. The FreeStyle Libre 3 Plus sensor is prescribed separately.

Yes. Omnipod 5 with the FreeStyle Libre 3 Plus sensor integration requires a new, compatible Pod. Specifically, you will need Omnipod 5 Pods compatible with the FreeStyle Libre 2 Plus and FreeStyle Libre 3 Plus sensors. Users currently prescribed Omnipod 5 Pods compatible with Dexcom G6 and FreeStyle Libre 2 Plus will automatically receive the new compatible Pods as inventory transitions. The FreeStyle Libre 3 Plus sensor is prescribed separately.

Some insurance plans, including certain Medicaid plans, require prescriptions to be filled at local brick-and-mortar retail pharmacies. Because the newest Pod experience is initially available primarily through ASPN, these patients may have delayed access until broad retail availability. Patients should continue through their in-network retail pharmacy and will receive compatible Pods as retail inventory transitions.

Patient experience may vary at launch depending on sensor and Pod variant. Patients with compatible Pods and the Omnipod 5 App software update will have access to the new Algorithm Enhancements, including the 100 mg/dL Target Glucose option, and, where applicable, the FreeStyle Libre 3 Plus sensor integration. Patients on older Pods will continue to receive their current Omnipod 5 experience until compatible Pods reach their pharmacy through normal refill cycles.

No. New-to-Omnipod 5 patients should be prescribed through ASPN pharmacy partners to access the newest Pod experience at launch. 

Existing Omnipod 5 patients continuing with their current sensor and the appropriate compatible Pod for that sensor should continue refilling through their current pharmacy, compatible Pods will appear in refills as channel inventory transitions. 

Where local-retail-pickup plan restrictions apply, patients will be routed to their in-network retail pharmacy.

Patient experience may vary depending on the Pods used. Pods included in Omnipod 5 Intro Kits may not match the Algorithm Enhancements available on refill Pods at launch, as kits transition through inventory. If access to the latest enhancements is clinically important for a new patient at start, prescribe their refill through ASPN pharmacy partners.

At launch, Omnipod 5 Intro Kits may still contain Pods from existing inventory. Updated Pods will be available in kits as inventory transitions. If a patient’s initial kit experience differs from their refill experience, contact Insulet Customer Care at 1-800-591-3455 Option 2 for assistance. If access to the full Algorithm Enhancements suite is clinically important at the point of new patient start, prescribe refill Pods through ASPN pharmacy partners per current launch guidance.

Availability will broaden as retail inventory transitions through the summer. 

Existing Omnipod 5 patients continuing with their current sensor and Pod combination will begin to see compatible Pods in refills automatically. 

No action is needed beyond accepting the Omnipod 5 App software update and consulting with your healthcare provider before changing settings.

There are no new NDC codes for Omnipod 5 Pods. NDC continuity was preserved for the Algorithm Enhancements, no new NDC was created. 

However, distinct sensor-compatible Pod variants exist (Omnipod 5 Pods compatible with Dexcom G6 and G7 CGM Systems, Omnipod 5 Pods compatible with the FreeStyle Libre 2 Plus and FreeStyle Libre 3 Plus sensors), and product naming may not update in all EHR systems simultaneously.

Product names may vary by EHR system and may not update immediately at launch. Providers should verify that both the Intro Kit and refill Pods indicate 'Libre' in the product name and use the current prescribing fact sheet for the latest product naming and NDC reference information. Compendia naming for Omnipod 5 Libre2Plus is expected to update to Omnipod 5 Libre as retail availability broadens.

At launch, the newest Pod experience is primarily available through ASPN pharmacy partners. Compatible Pods are entering retail pharmacies and availability will broaden through the summer. Patients on plans with network restrictions may have delayed access until retail inventory transitions in their pharmacy.

ASPN pharmacy partners cannot process prescriptions for plans that require local retail pickup, including certain Medicaid and government plans. These patients will be routed to their in-network retail pharmacy and will receive compatible Pods as retail inventory transitions. Because the newest Pod experience is initially available primarily through ASPN, these patients may experience delayed access until broad retail availability.

Continue prescribing through your usual pharmacy channel. Compatible Pods are entering retail pharmacies now, with availability broadening through the summer. Once a patient receives compatible Pods and accepts the Omnipod 5 App software update, they will have access to the new Algorithm Enhancements, including the 100 mg/dL Target Glucose option. The FreeStyle Libre 3 Plus sensor integration requires Omnipod 5 Pods compatible with the FreeStyle Libre 2 Plus and FreeStyle Libre 3 Plus sensors, which will reach broad retail availability through the summer.

The new Algorithm Enhancements (including the 100 mg/dL Target Glucose option) do not require formal re-training for current Omnipod 5 users. We recommend current users consult with their healthcare provider before changing settings. New users receive standard training as part of onboarding.

Yes. Once you accept the Omnipod 5 App software update and receive compatible Pods in your refills, you will need to update your Target Glucose settings within your Omnipod 5 App to 100 mg/dL. Please consult with your healthcare provider regarding your settings.

Yes. Omnipod 5 Pods compatible with Dexcom G6 and G7 CGM Systems will not support FreeStyle Libre sensors, and Omnipod 5 Pods compatible with FreeStyle Libre sensors will not support Dexcom CGM Systems. Users switching sensors will need to be prescribed the appropriate compatible Pod for their sensor. Omnipod 5 Pods compatible with the FreeStyle Libre 2 Plus and FreeStyle Libre 3 Plus sensors will automatically replace older Pods compatible with Dexcom G6 and FreeStyle Libre 2 Plus as inventory transitions.

If a user activates a Pod that does not support the 100 mg/dL Target Glucose option, including a Pod received in a future refill, the App will notify the user during Pod activation and provide the option to deactivate the Pod or continue activation. 

If the user continues, the App will set the Target Glucose to 110 mg/dL for that Pod session, since the 100 mg/dL setting is not supported by that Pod. The user can return to 100 mg/dL once they activate a compatible Pod again. 

The App will not automatically restore the 100 mg/dL setting, the user will need to manually update their Target Glucose and Correct Above Profile once they are using compatible Pods. Please consult with your healthcare provider regarding your settings.

Pods compatible with the FreeStyle Libre 3 Plus sensor are indicated on the upper-right corner of the box and the inner Tray Lid. The Omnipod 5 Pods compatible with Dexcom G6 and G7 CGM Systems will not support FreeStyle Libre sensors.

Yes. With the introduction of the FreeStyle Libre 3 Plus sensor integration, new Omnipod 5 Pods compatible with the FreeStyle Libre 2 Plus and FreeStyle Libre 3 Plus sensors are now available, indicated on the upper-right corner of the box. Omnipod 5 Pods compatible with Dexcom G6 and G7 CGM Systems will not support the FreeStyle Libre 2 Plus or FreeStyle Libre 3 Plus sensors.

Omnipod 5 with the FreeStyle Libre 3 Plus sensor integration is available on the dedicated Omnipod 5 Controller and compatible Android devices. For the current list of compatible devices, visit omnipod.com/compatibility.

The Omnipod 5 App with compatibility with the FreeStyle Libre 3 Plus sensor for iPhone is currently under development and not yet available. For a list of compatible devices visit omnipod.com/compatibility.

No. Changing the sensor used with Omnipod 5 does not restart adaptivity.

After launching Omnipod 5, feedback from healthcare providers highlighted the need for a 100 mg/dL Target Glucose option for certain users. Omnipod 5 continues to evolve while maintaining its proven clinical performance in tubeless automated insulin delivery.

Previously, users were asked to switch to Manual Mode for 5 minutes after acknowledging the advisory alarm. If users did not return to Automated Mode, automated insulin delivery would remain interrupted. Based on this, alarm handling was updated. The new Check Blood Glucose Advisory Alarm keeps users in Automated Mode during high glucose events and is designed to reduce interruptions and improve response to prolonged hyperglycemia.

Yes. All approved Target Glucose settings (110, 120, 130, 140, and 150 mg/dL) remain available with the new Algorithm Enhancements. The 100 mg/dL Target Glucose option is now also available with compatible Pods and the Omnipod 5 App software update.

No, you do not need a new prescription to take advantage of the 100 mg/dL Target Glucose option. However, we recommend consulting with your healthcare provider before changing settings.

After launching Omnipod 5, feedback from key opinion leaders and healthcare providers highlighted the need for a 100 mg/dL Target Glucose option for certain users. Omnipod 5 continues to evolve while maintaining its proven clinical performance. The addition of the 100 mg/dL Target Glucose option reflects the company's commitment to responding to HCP and user needs.

Yes. Users using the FreeStyle Libre 2 Plus sensor can access the new Algorithm Enhancements, including the 100 mg/dL Target Glucose option, once they have completed the Omnipod 5 App software update and are using Omnipod 5 Pods compatible with the FreeStyle Libre 2 Plus and FreeStyle Libre 3 Plus sensors. 

Users still using older Pods compatible with Dexcom G6 and FreeStyle Libre 2 Plus will not have access to the new enhancements until they receive compatible Pods. 

Compatible Pods are entering retail pharmacies and availability will broaden through the summer.

The simulated analysis of the 100 mg/dL Target Glucose setting compared with the 110–150 mg/dL Target Glucose settings in a real-world population of people with Type 1 diabetes using Omnipod 5 did not show a meaningful impact on time below range.²

The simulated analysis demonstrated improved Time in Range (TIR) results at the 100 mg/dL Target Glucose setting compared with results at the 110–150 mg/dL Target Glucose settings, with no meaningful impact on time below range, in a real-world population of people with Type 1 diabetes using Omnipod 5.²

For pharmacy or coverage processing questions, contact Insulet Customer Care at 1-800-591-3455 Option 2. For payer or formulary-level questions, contact your Insulet field representative or Inside Sales.

For new-to-Omnipod 5 users, prescribe through ASPN pharmacy partners. 

For existing users continuing with their current sensor and the appropriate compatible Pod for that sensor, continue with their current refill pathway. Existing users switching sensor integrations, including switching to Omnipod 5 with the FreeStyle Libre 3 Plus sensor integration, should confirm the appropriate compatible Pod prescription with their healthcare provider.

For specific user scenarios that do not fit either pathway, contact your Insulet field representative or Inside Sales. For pharmacy-level questions about ASPN processing, contact Insulet Customer Care at 1-800-591-3455 Option 2.

Insulet Product Support (Option 1) addresses software update availability and Pod functionality questions. Insulet Customer Care (Option 2) addresses Pod supply, refill, and access questions. Both are reached at 1-800-591-3455.

Product names may vary by EHR system and may not update immediately at launch. For Pods compatible with Dexcom CGM Systems, EHR naming is unchanged. For Pods compatible with FreeStyle Libre sensors, the product name "Omnipod 5 Libre2Plus" will update to "Omnipod 5 Libre" in compendia as retail availability broadens. Because EHR systems update on different timelines, providers may continue to see legacy naming variants. For specific EHR system update questions, HCP offices should contact their EHR administrator. For continued issues, contact your Insulet field representative or Inside Sales for prescribing-level support, and Insulet Customer Care at 1-800-591-3455 Option 2 for pharmacy-level support.

For prescribing or getting the FreeStyle Libre 3 Plus sensor, direct users to Abbott Consumer Relations at 1-844-330-5535.

Yes. The full Algorithm Enhancements suite is available once the Omnipod 5 App software update is accepted and the user is using either Omnipod 5 Pods compatible with Dexcom G6 and G7 CGM Systems identified by a black dot with "R1" on the Tray Lid and box label, or Omnipod 5 Pods compatible with the FreeStyle Libre 2 Plus and FreeStyle Libre 3 Plus sensors. 

Omnipod 5 Pods compatible with Dexcom G6 and G7 CGM Systems manufactured after January 1, 2026 support the new 100 mg/dL Target Glucose option, however, the full Algorithm Enhancements suite requires Pods identified by the black dot with "R1." Older Omnipod 5 Pods compatible with Dexcom G6 and FreeStyle Libre 2 Plus CGM sensors do not enable the Algorithm Enhancements.